One of the most exciting solutions to such problems is the controlled-release of protein/peptide-based drugs from biodegradable polymers.
Since it has been demonstrated that large molecules including proteins can be released continuously from biodegradable polymers, the application of such polymers in the controlled-release of proteins and peptides has grown enormously.
These systems provide many advantages over conventional therapeutic approaches. For example, they can be constructed to deliver an active ingredient at a constant rate for a prolonged time-span thus reducing side effects (constant dosage for extended period). They can target specific tissues, extend the half-life of the drug, and also enhance its serum stability. In addition, controlled-release protein injectables with a reduced total number of administrations improve patient compliance and comfort, as well as enhance control over drug levels in the blood.